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陈德宇学术副院长

1.基本情况：

陈德宇，男，72年4月生，安徽太湖人，理学博士，教授，硕士生导师。中国民主同盟盟员。

Tel:18269992453, 0558-2596113(O)

Email: chendeyu7104@aliyun.com

2.学习、工作简历

1990.9-1994.7就读于安徽科技学院，获理学学士学位；

1994.7-1996.9工作于安徽省第六监狱管理局；

1996.9-1998.6就读于安徽农业大学，获工学学士学位；

1998.7-2002.8于阜阳师范学院生物系任讲师；

2002.9-2005.6就读于南京师范大学生命科学院动物学专业，获理学博士学位；

2005.7-2007.3于阜阳师范学院生物系任副教授；

2006.1-2009.9于阜阳师范学院任《阜阳师范学院学报（自然科学版）》副主编（副处级）；

2007.3- 2009.9工作于汕头大学医学院博士后流动站；

2009.9- 2014.7阜阳师范学院教授，阜阳师范学院科研处副处长。

2012.9-2013.9中国科学技术大学访问学者。

2014.7- 阜阳师范大学教授，《阜阳师范学院学报（自然科学版）》主编。

2024.12- 阜阳医学院学术副院长

3.主持的国家及省部级及以上科研课题

名称	基金来源	基金号	备注
低活力精子miRNA表达谱的建立及其对精子发生的影响	国家自然科学基金	31071317	主持人，结题
miR-122-5p介导的occludin对支持细胞间紧密连接的调控机制研究	国家自然科学基金	81771567	主持人，进行中
精子miRNA对受精和胚胎发育的影响	教育部科学技术重点研究项目	210104	主持人，结题
无架瓜萎技术在产业扶贫中的推广与应用	校地合作横向科研项目	XDHX2016022	主持人,进行中
miR-326介导的mTOR通路对支持细胞细胞骨架的调控机制研究	省高校自然科学重大、重点研究项目	KJ2017A338	主持人,进行中
性别决定技术在狐狸产业化养殖业中的应用研究	安徽省科技攻关项目	12010302066	主持人，结题
利用外部科技资源提升皖北产业结构研究	安徽省软科学研究计划项目	11020503042	主持人，结题
弱精症患者精子中MRNA表达谱的构建	广东省科技计划项目	2008B03031242	主持人，结题
弱精症患者精子中MICRORNA表达谱的建立及分析	广东省自然科学基金	81515031020000027	主持人，结题
精子膜蛋白单链抗体的制备及其在阴道内的抑精研究	广东省自然科学基金	7300865	主持人，结题

4.学术奖励及荣誉称号

1. 陈德宇，朱茂英，刘生杰，崔亚东.精子数量及精子活力的调控机制及其在避孕中的应用研究.安徽省科技进步三等奖，2015；

2. Chen De-yu(陈德宇), Liu Sheng-jie, Zhu Mao-ying, Cui Ya-dong，Li Wen-yong，Huang Yu-feng. Different expression of lipocalin-type prostaglandin D synthase in rat epididymidis.安徽省第七届自然科学优秀论文二等奖，2013；

3. “阜阳市第七批专业技术拔尖人才”称号，2015;

4. “阜阳师范学院优秀科技工作者”称号, 2014.

5. Chen De-Yu(陈德宇), Li-Min Liu, Dong-Qing Xie，Xu lan, Tian-Hua Huang. In vitro and in vivo studies evaluating antisemen antibodies as a potential spermicidal agent in hamsters.广东省科学技术协会第二届南粤科技创新优秀论文三等奖，2010；

   5.社会兼职

1）杂志编委：《Systematic Bioscience and Engineering》编委、《中华男科学杂志》编委、《癌变突变畸变》编委；

2）评审专家：国家自然科学基金网评专家、浙江省自然科学基金网评专家、江西省自然科学基金网评专家；

3）学会理事：安徽省学报学会理事、安徽省兽医学会理事、广东省环境毒理学会理事；

4）其他：安徽省科技特派员、阜阳市第五届政协委员、阜阳市阜阳师范大学民盟理科支部主委。

6. 实验技能

熟练掌握各类分子生物学及细胞生物学方面的各项技能：Recombinant DNA Technology, Protein expression and purification, Produce McAb, Produce recombinant ScFv (single-chain Fv), IVF, Immunohistochemistry, miRNA, Immunocytochemistry, RNAi, Flow cytometry

7. 主要学术论文

1. Zhu M, Lu J, Shen J, Fei L, Chen D（通讯作者）. A 22-amino-acid peptide regulates tight junctions through occludin and cell apoptosis. PeerJ. 2020 Nov 3;8:e10147. doi: 10.7717/peerj.10147. PMID: 33194394; PMCID: PMC7646304.

2. Liu L, Zhu M, Liu X, Fei L, Shen J, Chen D（通讯作者）. miR-122-5p regulates the tight junction of the blood-testis barrier of mice via occludin : miR-122-5p can regulate the tight junction. Basic Clin Androl. 2021 Apr 8;31(1):7. doi: 10.1186/s12610-021-00126-8. PMID: 33827415; PMCID: PMC8028252.

3. Zhu M, Fei L, Li D, Chen D（通讯作者）. Correlation Analysis of miR-122-5p and Occludin with Sperm Density in Oligospermia Patients' Sperm. Clin Lab. 2019 Mar 1;65(3). doi: 10.7754/Clin.Lab.2018.180814. PMID: 30868853.

4. Wang H, Tan X, Chen D（通讯作者）. Short peptide perturbs spermatogenesis via immune microenvironment dysregulation and mitochondrial imbalance. FEBS Open Bio. 2025 Sep;15(9):1485-1495. doi: 10.1002/2211-5463.70058. Epub 2025 May 22. PMID: 40405547; PMCID: PMC12401178.

5. Li H, Cheng L, Tao J, Chen D（通讯作者）, Zeng C. Knowledge and willingness to receive a COVID-19 vaccine: a survey from Anhui Province, China.Hum Vaccin Immunother. 2022 Dec 31;18(1):2024064. doi: 10.1080/21645515.2021.2024064. Epub 2022 Feb 7. PMID: 35130110; PMCID: PMC8993089.

6. Tan XF, Chen DY, Ding JY, Wu J. [Deletion of extracellular loops of occludin affects the tight junction of TM4 cells in mice]. Zhonghua Nan Ke Xue. 2020 Aug;26(8):675-680. Chinese. PMID: 33377726.

7. Shen JY, Zhu MY, Fei LM, Chen DY（通讯作者）. [SP1 identified as a transcription factor of miR-122-5p]. Zhonghua Nan Ke Xue. 2021 Jan;27(1):11-16. Chinese. PMID: 34914275.

8. Zhu MY, Shen JY, Fei LM, Chen DY（通讯作者）. [Construction of RNA interfering lentiviral vector of occludin and its role in tight junctions]. Zhonghua Nan Ke Xue. 2021 Jun;27(6):499-505. Chinese. PMID: 34914288.

9. Pu SC, Zhang Y, Lu N, Chen DY（通讯作者）. [Establishment of a mouse model of testicular Occludin gene knockout based on the CRE/LOXP system]. Zhonghua Nan Ke Xue. 2021 Aug;27(8):685-693. Chinese. PMID: 34914239.

10. 朱茂英,沈建云,费路敏, &陈德宇(通讯作者).Occludin的rna干扰慢病毒载体的构建及其在紧密连接中的功能研究.中华男科学杂志, 2021，27(6)499-465.

11. 沈建云,朱茂英,费路敏&陈德宇(通讯作者). SP1被鉴定为miR-122-5p的一个转录因子[J].中华男科学杂志, 2021，27(1),11-16.

12. 谭小方、陈德宇、丁家怡、吴洁. "闭合蛋白的胞外环缺失对小鼠TM4细胞紧密连接的影响分析."中华男科学杂志,2020，26（08）:4-9.

13. 刘明，陈德宇(通讯作者).瓜蒌皮中齐墩果酸的定量分析及其生物学功能研究.阜阳师范学院硕士研究生毕业论文.2018

14. 程丽芳,陈德宇(通讯作者).性别决定技术在银狐养殖产业中的应用研究.安徽大学硕士研究生毕业论文.2016

15. Wuyi LiuandChen De-Yu.Phylogeny, Functional Annotation, and Protein Interaction Network Analyses of the Xenopus tropicalis Basic Helix-Loop-Helix Transcription Factors.BioMed Research International.Volume 2013 (2013), Article ID 145037, 15 pages.http://dx.doi.org/10.1155/2013/145037.

16. Yuntao Ji,Chen De-Yu, Shuanglin Jiang and Changqing Qu. Effect of fasudil hydrochloride on the post-thaw viability of cryopreserved procine adipose-derived stem cells.CryoLetters,2014,35 (5), 356-360.

17. Chen De-Yu, Li-Min Liu, Dong-Qing Xie，Xu lan, Tian-Hua Huang.In vitro and in vivo studies evaluating antisemenantibodiesas a potential spermicidal agent in hamsters.Fertility and sterility.2009，92,(3):1116-1123．

18. Chen De-Yu, Li-Min Liu, Sheng-Jie Liu, Mao-Ying Zhu, Lan Xu, Tian-Hua Huang. Single-chain antibody against human lipocalin-type prostaglandin D synthase: construction, expression, purification, and activity assay.Biochemistry (Mosco).2008, 73(6):702-710.

19. Chen De-yu, Zhu Mao-ying, Cui Ya-dong, Huang Tian-hua. Relationship between Contents of Lipocalin-Type Prostaglandin D Synthase on the Surface of Infertility Sperm and in Seminal Plasma.Biochemistry (Mosco), 2007, 72(2):255-259.

20. Chen De-yu, Liu Sheng-jie, Zhu Mao-ying, Cui Ya-dong，Li Wen-yong，Huang Yu-feng. Different expression of lipocalin-type prostaglandin D synthase in rat epididymidis.Animal reproduction science，2007，98(3-4)：302-310.

21. Chen De-yu, Wang Jun-Jun, Huang Yu-Feng, Zhou Kai-Ya.Relationship between lipocalin-type prostaglandin D synthase and α-glucosidase in azoospermia seminal plasma.Clinica chimica acta, 2005, 354(1-2):69-76.

22. Chen Deyu, Zhou Kaiya, Huang Yufeng. Expression of rat L-PGDS by Picha Pastoris and distribution of L-PGDS on sperm.ChineseJournal ofBiotechnology, 2004, 20(6):896-900.[Chinese]

23. Chen Deyu, Zhou Kaiya, Lu Huiming, Huang Yufeng. Distribution and localization of lipocalin-type prostaglandin D synthase in rat testis and epididymidis. Acta Anatomica Sinica,2004, 35(4):443-445. [Chinese]

24. Chen Deyu, Huang Yufeng. Advance in research on the targent antigens of antisperm antibosies. National Journal of Andrology,2004, 10(6):458-464. [Chinese]

25. Chen Deyu, Huang Yufeng, Zhou Kaiya. Structure,localization and distribution of lipocalin-type prostaglandin D synthase. National Journal of Andrology,2004,10(2):134-138. [Chinese]

26. Chen DeYu, Zhu GuoHua , Huang YuFeng , Zhou KaiYa. Lipocalin2type prostaglandin D synthase:preparation of monoclonal antibodies and localization on human sperm. Journal of Chinese Immunolgy,2005,21(3):201-204. [Chinese]

27. Chen DeYu, Huang Yu-Feng. Sertoli-Sertoli Tight Junction and Male Contraceptive.Chinese Journal of Cell Biology, 2005, 27: 295-300. [Chinese]

28. Chen Deyu, Zhu Guohua, Huang Yufeng. Application of sandwich ELISA of L-PGDS in human seminal plasma.Chinese Journal of Laboratory Medicine,2005,28(3):295-296.[Chinese].

29. Chen Deyu,LIU Li-min,XIE Qing-dong,HUANG Tian-hua.Experimental Research on Anti-semen Antibody of Golden Hamster as Spermicide.Carcinogenesis,Teratogenesis & Mutagenesis.2008,20(2):139-142[Chinese]

30. Chen Deyu,LIU Li-min,XIE Qing-dong,HUANG Tian-hua.Influence of Anti-semen Antibody on Function of Mitochondria.Journal of Shantou University Medical College.2008, 21(1):4-7.[Chinese]

31. Chen Deyu.Role of Supervisor in Raising Quality of Graduation Thesis of College Students.Journal of Fuyang Teachers College(Natural Science).2008,25(4):76-79.[Chinese]

32. Chen Deyu,LIU Li-min,XIE Qingdong,HUANG Tian-hua.Effect of Anti-sperm Antibody on Golden Hamster Vagina.Journal of Fuyang Teachers College(Natural Science),2007,24(4):12-14[Chinese].

33. Chen Deyu,LIU Li-min,HUANG Tian-hua.Construction and analysis of miRNA prof iles in the spermof patien ts with asthenospermia.Journal of Fuyang Teachers College (Natural Sciences),2006, 26(2):47-51.

34. Chen Deyu,Liu Sheng-jie,ZHU Mao-ying.Advances in Male Contraceptive Vaccine.Journal of Fuyang Teachers College Natural Sciences,2006, 23(4):2-5[Chinese].

35. ZHU Mao-ying,LIU Sheng-jie;Chen Deyu.The correlation between lipocalin-type prostaglandin D synthase and alpha-glucosidase in seminal plasma.Journal of Reproductive Medicine,2006,15(3):165-167.[Chinese]

36. Chen Deyu,HUANG Yu-feng,LU Hui-min,ZHOU Kai-ya.Expression of lipocalin-type prostaglandin D synthase gene in rat testis and epididymis.Chinese Journal of Veterinary Science and Technology.2004,34(5):55-57[Chinese].

37. Zhu Guohua,Chen Deyu,Xu XiaofengH,uang Yufeng.Constructing Human-mouse Chimeric Antibody Gene to L-PGDS.Journal of Nanjing Normal University(Natural Science Edition),2005,28(1):98-102[Chinese].

38. Huang Yufeng,Chen Deyu,Ge Yifeng,Jin Baofang,Yan Chunming,Rui Hongying,Lu Jinchun.Analysis of the Infection of Sexually Transmitted Diseases among High-risk Population in Nanjing.Nationlal Journal of Andrology.2004, 10(11):815-819[Chinese].

39. Huang Yufeng,Chen Deyu,Jin Baofang,Ge Yifeng,Wan Chuandan,Zhu Zhaoping,Zhu Guohua,Hong Ping.Investigation of STD/AIDS Related KABP among the High-risk Population.Nationlal Journal of Andrology, 2004,10(12):894-897[Chinese].

40. ZHANG Qiu-ju,HUANG Tian-hua,XIE Qing-dong,TAN Xiao-fang,LIU Ge-fei,Chen Deyu,ZHOU Xiao-ling.Protein Expression of Human Spermatozoa-mediated HBs Gene and HBc Gene in Early Embryonic Cells.Carcinogenesis,Teratogenesis & Mutagenesis.2008,20(3):185-189[Chinese].

    8. 编著、专利及标准

41. 陈德宇.前列腺素D合成酶和精子RNA在男性生殖中的基础研究(M).合肥工业出版社.2018.

42. 于干,陈德宇.网络优化算法及函数优化问题研究(M) .合肥工业出版社.2018.

43. 地方标准:陈德宇,朱茂英,刘生杰.蓝狐快速繁殖技术规程.安徽省地方标准(皖质函[2015]195号),2015.(见附件)

44. 专利：陈德宇,狐狸X精子分离方法.申请号: 201510388072.2(公开（公告）号: CN104962513A；IPC分类号:C12N5/076

45. 专利：陈德宇,狐狸精液稀释液.申请号: 201510388030.9，公开（公告）号: CN105010306A，IPC分类号:A01N1/02